产品编号:I-451-10
产品描述:Recombinant Rat IL-13 (113 a.a.)
反应种属:
实验方法:
标记:
规格:10ug
供应商:Leinco
价格(RMB):5205.00
订购:
说明书:
Recombinant Rat Interleukin-13, 113 a.a. (IL-13)
(ALRH, BHR1, MGC116786, P600, NC30)
Prod. No.: I-451
Source E. Coli
Pkg. Size: 1 mg, 10 µg
Description
Background:
Interleukin 13 (IL-13) is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells1, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα), which is also a component of the IL-4 receptor, and at least one of two known IL-13-specific binding chains.1 The functions of IL-13 overlap considerably with those of IL-4. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
Source
E. Coli
State of Matter
Purity
>98% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
The biological activity of Rat Interleukin-13, 113 a.a., is determined by by the dose-dependent proliferation of TF-1 cells. The expected ED50 for this effect is <5.0 ng/ml, corresponding to a specific activity of >2 x 105 units/mg.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSIVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH
References
1. Wynn TA. et al. (2003) Annu Rev Immunol. 21: 425
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