产品编号:I-239-1
产品描述:Recombinant Mouse IGF-I
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
说明书:
Recombinant Mouse Insulin Like Growth Factor-I (IGF-I)
Purified No Carrier Protein
(Somatamedin C, IGF-IA)
Prod. No.: I-239
Source E. coli
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
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