产品编号:B419
产品描述:Anti-Human BMP-7-Biotin
反应种属:human
实验方法:ELISA, WB
标记:
规格:50ug
供应商:leinco
价格(RMB):5550.00
订购:
说明书:
Rabbit Anti-Human Bone Morphogenetic Protein-7 (BMP-7)
Biotin
(Osteogenic Protein 1 [OP-1])
Polyclonal Antibody
Prod. No.: B419
Host: Rabbit
Pkg. Size: 1 mg, 50 µg
Description
Specificity:
Rabbit Anti-Human Bone Morphogenetic Protein-7 (BMP-7) recognizes Human Bone Morphogenetic Protein-7. This antigen affinity purified polyclonal antibody was purified using immobilized antigen agarose chromotography.
Background:
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.
BMP's are evolutionarily conseved acrross the animal species. For example human and mouse share 98% sequence identity of the mature protein. BMP-7 is expressed as a large precursor protein cleaved at the dibasic (RXXR) site to release the carboxy-terminal domain. Biologically active BMP-7 has been shown to exhib its cellular responses by the formation of hetero-oligomeric complexes of type I and II serine/threonine kinase receptors. BMP's 5,6,7,and 8 are in the same subgroup based on amino acid sequence similarity.
Immunogen
Purified Recombinant Human BMP-7 (>98%)
Formulation
This biotinylated antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Reconstitution
This biotinylated antigen affinity purified polyclonal antibody should be aseptically reconstituted in sterile 1X PBS containing 0.1% BSA to a final concentration of 50 µg/ml.
Storage and Stability
This lyophilized biotinylated polyclonal antibody should be stored desiccated at -20°C. The reconstituted conjugate is stable for at least one month when stored at 2 - 8°C. For long term storage aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid More Than One Freeze Thaw Cycle.
Reported Applications
WB
Related Products
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Anti-Human BMP-7 (Leinco Prod. No.: B430)
Recombinant Human BMP-7 (Leinco Prod. No.: B525)
Anti-Human BMP-7 (Leinco Prod. No.: B575)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
