产品编号:T233
产品描述:Anti-Human TL-1A
反应种属:human
实验方法:ELISA, WB
标记:
规格:100ug
供应商:leinco
价格(RMB):5325.00
订购:
说明书:
Goat Anti-Human TNF-Ligand-Related Molecule 1-A (TL1-A)
Antigen Affinity Purified
(TNFSF15, MGC129934, MGC129935, TL1, VEGI, VEGI192A)
Polyclonal Antibody
Prod. No.: T233
Host: Goat
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C
Description
Specificity:
Goat Anti-Human TNF-Ligand-Related Molecule 1-A (TL1-A) recognizes Human TL1-A. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Antigen Distribution:
Human TL-1A is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon.
Background:
TNF-ligand-related molecule 1A (TL1A), is an endothelium-derived T cell costimulator and a ligand for tumor necrosis factor receptor superfamily members DR3 and decoy receptor 3.1 TL1A binds to the death-domain receptor (DR)3 and provides costimulatory signals to activated lymphocytes. Through this interaction, TL1A induces secretion of IFN-γ. Blockade of the TL1A/DR3 pathway may offer therapeutic opportunities in Crohn's disease.2
Known Species Cross Reactivity: Hu+
Immunogen
Purified Recombinant Human TL-1A (>98%)
Formulation
This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Reconstitution
We suggest aseptically reconstituting this lyophilized, antigen affinity purified polyclonal antibody with 1 ml of sterile 1X PBS pH 7.2-7.3. This will result in a final antibody concentration of 0.1 mg/ml.
Endotoxin
<0.1 EU/µg as determined by the LAL method
Storage and Stability
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Reported Applications
Indirect ELISA, WB
References
1. Wei P et al. (2003) J Biol Chem. 278: 39251
2. Fabio Cominelli et al. (2006) PNAS 103: 8441
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TL1-A (NT) Blocking Peptide (Leinco Prod. No.: T328)
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
