产品编号:G592
产品描述:Anti-Human GDF-3
反应种属:human
实验方法:ELISA, ELISA, N, WB
标记:
规格:100ug
供应商:leinco
价格(RMB):5775.00
订购:
说明书:
Rabbit Anti-Human Growth and Differentiation Factor-3 (GDF-3)
Antigen Affinity Purified
(Vgr-2, UNQ222/PRO248)
Polyclonal Antibody
Prod. No.: G592
Host: Rabbit
Pkg. Size: 1 mg, 100 µg
Storage: -20°C
Description
Specificity:
Rabbit Anti-Human Growth and Differentiation Factor-3 (GDF-3) recognizes Human GDF-3. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Background:
Growth differentiation factor-3 (GDF3) also known as Vg-related gene 2 (Vgr-2), is a protein belonging to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members called Vg1, BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.1 Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.2,3
GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.4 GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.5
Immunogen
Purified Recombinant Human GDF-3 (>98%)
Formulation
This antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Reconstitution
Aseptically reconstitute this antigen affinity purified polyclonal antibody using sterile deionized water to a concentration >0.2 mg/ml.
Storage and Stability
The lyophilized antibody should be stored desiccated at -20°C. The reconstituted antibody can be stored for at least six weeks at 4°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
ELISA Cap, Indirect ELISA, N, WB
References
1. van den Eijnden-van Raaij A et al. (1998) Oncogene 16: 95
2. Brown C et al. (2006) Development 133: 319
3. Yu L et al. (2005) Neurosci Lett 389: 83
4. Brivanlou A et al. (2006) Cell Cycle 5: 1069
5. Brivanlou AH. et al. (2006) Developement 133: 209
Related Products
Anti-Human GDF-3-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: G593)
Recombinant Human GDF-3 (Leinco Prod. No.: G584)
Recombinant Human GDF-3 (Leinco Prod. No.: G710)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
