产品编号:C1233
产品描述:Anti-Human CTRP1(NT)
反应种属:mouse, human, rat
实验方法:WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5700.00
订购:
说明书:
Rabbit Anti-Human CTRP1
Purified No Carrier Protein
(G Protein Coupled Receptor Interacting Protein 1, GIP )
Polyclonal Antibody
Prod. No.: C1233
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human CTRP1 recognizes an epitope near the N-terminus of Human, Mouse and Rat CTRP1. This polyclonal antibody was purified using affinity chromatography.
Background:
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-related proteins (CTRPs) 1-7.2 Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues.3 These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene.4 In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.3
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
CTRP1 (NT) Blocking Peptide (Leinco Prod. No.: C1259)
Blocking Peptide
CTRP1 (NT) Blocking Peptide (Leinco Prod. No.: C1259)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
Western Blotting: This antibody can be used to detect Human, Mouse and Rat CTRP1 by Western blot analysis at a concentration of 1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is Human Kidney Tissue Lysate (Leinco Prod. No.: H1409)
References
1. Fantuzzi, G. (2005) J. Allergy Clin. Immunol. 115:911
2. Tsao, T. S. et al. (2002) Euro. J. Pharmacol. 440:213
3. Wong, G. W. et al. (2004) Proc. Natl. Acad. Sci. USA 101:10302
4. Shapiro, L. et al. (1998) Curr. Biol. 8:335
Related Products
CTRP1 (NT) Blocking Peptide (Leinco Prod. No.: C1259)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
Human Kidney Tissue Lysate (Leinco Prod. No.: H1409)
CTRP1 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: C1258)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
.jpg)
