产品编号:L103
产品描述:Anti-Human HPL Purified
反应种属:human
实验方法:
标记:
规格:1.0 mg
供应商:leinco
价格(RMB):2670.00
订购:
说明书:
Anti-Human Placental Lactogen (HPL)
Purified No Carrier Protein
Monoclonal Antibody
Prod. No.: L103
Clone: 178
Isotype: Mouse IgG
Conc.: 1.0 mg/ml
Pkg. Size: 1.0 mg
Description
Specificity:
Mouse Anti-Human Placental Lactogen (Clone 178) recognizes Human Placental Lactogen. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
Human placental lactogen (HPL), also called human chorionic somatomammotropin, is a polypeptide placental hormone. Its structure and function is similar to that of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. HPL consists of 190 amino acids that are linked by two disulfite bonds and is secreted by the syncytiotrophoblast during pregnancy. Its molecular weight is 22,125. Like human growth hormone HPL is encoded by genes on chromosome 17q22-24. Its biologic half-life is 15 minutes. HPL affects the metabolic system of the maternal organism. HPL increases production of insulin and IGF-1 and increases insulin resistance and carbohydrate intolerance. Chronic hypoglycemia leads to a rise in HPL. HPL induces lipolysis with the release of free fatty acids, increase in insulin secretion and insulin resistance. With fasting and release of HPL, free fatty acids become available for the maternal organism as fuel, so that relatively more glucose can be utilized by the fetus. Also, ketones formed from free fatty acids can cross the placenta and be used by the fetus. These events support energy supply to the fetus in states of starvation.
Affinity:
8 X 109
Host Species
Mouse
Immunogen
Purified Recombinant Human Placental Lactogen (>98%)
Formulation
This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09% sodium azide.
Cross Reactivity
Human prolactin < 0.01%. Human growth hormone < 0.01%.
Storage and Stability
For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Related Products
Anti-Human Placental Lactogen Horseradish Peroxidase (Leinco Prod. No.: H123)
Human Placental Lactogen (HPL) MICRO-ELISA Test Kit (Leinco Prod. No.: T115)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
